Bromine → 5-Bromo-7-chloro-2-methylquinolin-6-ol
反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][C:3]=1[OH:13].[Br:14]Br>C(O)(=O)C>[Br:14][C:4]1[C:3]([OH:13])=[C:2]([Cl:1])[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2参加物
4
実験手順
To a stirred solution of 7-chloro-2-methylquinolin-6-ol (1C) (450 mg, 2.3 mmol) in acetic acid (15 mL) was added Br2 (0.13 mL, 2.4 mmol) at ambient temperature. The mixture was stirred at ambient temperature for 2 hours. The solid that formed was filtered and collected to give 1D as an off-white solid as the HBr salt (847 mg, 100%). LCMS-ESI+ (m/z): 281.1, 283.1 (M+H)+.
後処理
- customThe solid that formed
- filtrationwas filtered
- customcollected
出典と根拠
- ORDレコード
- ord-004a15b9a8ca4b57a25185195e3b21ed
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09296758B2
反応ノート
読み込み中…