Thiophene-3-boronic acid → 1-isobutyl-8-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine

HRID 9368

反応式

HRID 9368 の反応式
Br[C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7]([NH2:12])[C:6]3[N:13]=[CH:14][N:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:5]=3[C:4]=2[CH:3]=1.[S:20]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21]1>>[CH2:16]([N:15]1[C:5]2[C:4]3[CH:3]=[C:2]([C:22]4[CH:23]=[CH:24][S:20][CH:21]=4)[CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([NH2:12])[C:6]=2[N:13]=[CH:14]1)[CH:17]([CH3:19])[CH3:18]

参加物

3

反応物 2

HCID 581760Thiophene-3-boronic acidHCID 111745978-bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

生成物 1

HCID 219841791-isobutyl-8-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine

実験手順

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and thiophene-3-boronic acid were coupled according to the general procedure described in Part J of Example 1. Recrystallization from isopropanol followed by chromatography on silica gel (7% methanol in CH2Cl2) afforded 1-isobutyl-8-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. 235–236° C.

後処理

  1. customRecrystallization from isopropanol

出典と根拠

ORDレコード
ord-b5404f3d81c74fca9c293d91f37982f0
出典データセット
uspto-grants-2006_08
特許番号
US07091214B2

関連ノート

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