Cyclohexyl isocyanate → N-cyclohexyl-N'-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea

HRID 9409

反応式

HRID 9409 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][C:16]([CH3:19])([NH2:18])[CH3:17])=[CH:11][CH:10]=[C:9]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:8]=2)([O-:3])=[O:2].[CH:26]1([N:32]=[C:33]=[O:34])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>ClCCl>[CH:26]1([NH:32][C:33]([NH:18][C:16]([CH3:19])([CH3:17])[CH2:15][NH:14][C:13]2[C:12]3[C:7](=[CH:8][C:9]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)=[CH:10][CH:11]=3)[N:6]=[CH:5][C:4]=2[N+:1]([O-:3])=[O:2])=[O:34])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

参加物

4

反応物 2

HCID 18502Cyclohexyl isocyanateHCID 86593761N1-(3-nitro-7-phenylquinolin-4-yl)-2-methylpropane-1,2-diamine

生成物 1

HCID 21984292N-cyclohexyl-N'-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of N1-(3-nitro-7-phenylquinolin-4-yl)-2-methylpropane-1,2-diamine (3.56 g, 10.6 mmol) in dichloromethane (100 mL) was cooled to 0° C. Cyclohexyl isocyanate (3.00 mL, 23.5 mmol) was added over the course of a day, and the reaction was stirred at ambient temperature for three days. The solvent was removed under reduced pressure. Xylenes (3 cx 100 mL) were added and removed under reduced pressure to provide N-cyclohexyl-N′-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea as a yellow solid.

後処理

  1. customThe solvent was removed under reduced pressure
  2. additionXylenes (3 cx 100 mL) were added
  3. customremoved under reduced pressure

出典と根拠

ORDレコード
ord-9d81f920428647a890f47a570c783a86
出典データセット
uspto-grants-2006_08
特許番号
US07091214B2

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