化工社化工社 化学情報印刷レポート · 研究参考用
4-Amino-1-butanol → 4-(7-Bromo-3-nitroquinolin-4-ylamino)butan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-1-butanol | HCID 25868 | — |
| 反応物 | 7-Bromo-4-chloro-3-nitroquinoline | HCID 21984361 | — |
| 生成物 | 4-(7-Bromo-3-nitroquinolin-4-ylamino)butan-1-ol | HCID 21984370 | 89.1% |
反応手順
A modification of the method described in Part E of Example 1 was used to treat 7-bromo-4-chloro-3-nitroquinoline (20.0 g, 69.6 mmol) with 4-amino-1-butanol (6.9 mL, 76.5 mmol). The addition of 4-amino-1-butanol was carried out at ambient temperature. The product, 4-(7-bromo-3-nitroquinolin-4-ylamino)butan-1-ol (21.1 g) was isolated as a yellow solid and used without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091214B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-27596081b9574913b377010ca438e260 |
| 出典メモ | uspto-grants-2006_08 |