Ethoxyacetyl chloride → N-[7-bromo-4-(4-chlorobutylamino)quinolin-3-yl]-2-ethoxyacetamide hydrochloride
反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][Cl:18])=[C:7]([NH2:12])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:19]([O:21][CH2:22][C:23](Cl)=[O:24])[CH3:20]>>[ClH:18].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][Cl:18])=[C:7]([NH:12][C:23](=[O:24])[CH2:22][O:21][CH2:19][CH3:20])[CH:8]=[N:9]2)=[CH:4][CH:3]=1参加物
3
実験手順
A modification of the method described in Part C of Examples 125–135 was used to treat 7-bromo-N4-(4-chlorobutyl)quinoline-3,4-diamine (7.25 g, 22.1 mmol) with ethoxyacetyl chloride (2.76 mL, 24.3 mmol). After the reaction was stirred for one hour, it was concentrated under reduced pressure to provide N-[7-bromo-4-(4-chlorobutylamino)quinolin-3-yl]-2-ethoxyacetamide hydrochloride as a yellow solid.
後処理
- concentrationit was concentrated under reduced pressure