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2,2-Dimethyl-1,3-dioxane-4,6-dione → 5-[(3-Benzylphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | Benzenamine, 4-(phenylmethyl)- | HCID 136914 | — |
| 反応物 | 3-Benzylaniline | HCID 308869 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-[(3-Benzylphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione | HCID 21984288 | — |
| 生成物 | 5-[(4-Benzylphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione | HCID 21984400 | — |
反応手順
Triethyl orthoformate (10.0 mL, 60.1 mmol), Meldrum's acid (8.2 g, 57 mmol), and either 3-benzyl aniline or 4-benzyl aniline (10.0 g, 54.6 mmol) as indicated in the table below in methanol (303 mL) were combined and treated according to the method described in Part A of Example 1 to provide 5-[(3-benzylphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (15.5 g) or 5-[(4-benzylphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (15.2 g), respectively.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091214B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-1497b3ef15dc4b0aace9e821cdb10a10 |
| 出典メモ | uspto-grants-2006_08 |