Triethylamine → 1-(6-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

HRID 9458

反応式

HRID 9458 の反応式
[NH2:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4].[CH2:7]([C:14]1[CH:23]=[C:22]2[C:17]([C:18](Cl)=[C:19]([N+:24]([O-:26])=[O:25])[CH:20]=[N:21]2)=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH2:28]([C:35]1[CH:36]=[C:37]2[C:42](=[CH:43][CH:44]=1)[N:41]=[CH:40][C:39]([N+:45]([O-:47])=[O:46])=[C:38]2Cl)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.C(N(CC)CC)C>ClCCl>[CH2:7]([C:14]1[CH:23]=[C:22]2[C:17]([C:18]([NH:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4])=[C:19]([N+:24]([O-:26])=[O:25])[CH:20]=[N:21]2)=[CH:16][CH:15]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1.[CH2:28]([C:35]1[CH:36]=[C:37]2[C:42](=[CH:43][CH:44]=1)[N:41]=[CH:40][C:39]([N+:45]([O-:47])=[O:46])=[C:38]2[NH:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

参加物

7

反応物 4

HCID 8471TriethylamineHCID 951022-Propanol, 1-amino-2-methyl-HCID 219841937-Benzyl-4-chloro-3-nitroquinolineHCID 219842266-Benzyl-4-chloro-3-nitroquinoline

生成物 2

HCID 219844101-(6-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-olHCID 219844521-(7-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Under a nitrogen atmosphere, 1-amino-2-methylpropan-2-ol (1.2 equivalents) was added to a 0.2 M solution of 7-benzyl-4-chloro-3-nitroquinoline or 6-benzyl-4-chloro-3-nitroquinoline (1 equivalent) and triethylamine (3 equivalents) in dichloromethane, and the reaction was stirred overnight at ambient temperature. The volatiles were removed under reduced pressure, and the residue was stirred with water (50 mL) for one hour. The resulting yellow solid was isolated by filtration and washed with water to provide 1-(7-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol or 1-(6-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol, respectively.

後処理

  1. customThe volatiles were removed under reduced pressure
  2. stirringthe residue was stirred with water (50 mL) for one hour
  3. customThe resulting yellow solid was isolated by filtration
  4. washwashed with water

出典と根拠

ORDレコード
ord-a26247a753df407cb8aa5733bcc350c4
出典データセット
uspto-grants-2006_08
特許番号
US07091214B2

関連ノート

読み込み中…