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5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione → 5-Bromoquinolin-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione | HCID 17252219 | — |
| 溶媒 | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| 生成物 | 5-Bromoquinolin-4-ol | HCID 178418724 | — |
| 生成物 | HCID 178418765 | HCID 178418765 | — |
反応手順
5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (32.6 g, 0.100 mol) was heated at 250° C. in DOWTHERM A heat transfer fluid for one hour, and then the reaction was allowed to cool to ambient temperature. A precipitate formed upon cooling and was isolated by filtration and washed with diethyl ether to provide 7-bromoquinolin-4-ol and 5-bromoquinolin-4-ol in a 2:1 ratio.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091214B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-b1f865ef25a04e39839832f0be237929 |
| 出典メモ | uspto-grants-2006_08 |