1H-1,2,4-Triazole → 1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole
反応式
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9](Cl)=[O:10]>C(OCC)(=O)C>[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9]([N:1]1[CH:5]=[N:4][CH:3]=[N:2]1)=[O:10]参加物
4
実験手順
To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.
後処理
- stirringThe mixture was stirred for 30 min
- filtrationfiltered
- customThe residue obtained
- customafter evaporation of the solvent
- dissolutionwas redissolved in dichloromethane (25 mL)
- filtrationfiltered
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-0c18d3271e484f0f9ae2b826de5610c7
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723470
反応ノート
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