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Triethyl phosphite → Diethyl (2,3,3-trifluro-2propenyl)phosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethyl phosphite | HCID 31215 | — |
| 反応物 | 1-Propene, 3-bromo-1,1,2-trifluoro- | HCID 10631079 | — |
| 生成物 | Diethyl (1,1,2-trifluoro-2-propenyl)phosphonate | HCID 53986716 | 11% |
| 生成物 | Diethyl (2,3,3-trifluro-2propenyl)phosphonate | HCID 54339468 | 14% |
反応手順
A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723470 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-69bdc7c6a2fb4d4987a431b8e37f7f33 |
| 出典メモ | uspto-grants-1998_03 |