関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4'-Hydroxy-3'-methylacetophenone | HCID 70135 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Ethyl 2-(4-acetyl-2-methylphenoxy)acetate | HCID 21986544 | — |
反応手順
1-(4-Hydroxy-3-methylphenyl)ethanone (90 g) and cesium carbonate (216 g) were stirred in acetonitrile (900 ml) at room temperature under nitrogen for 10 minutes. Ethyl bromoacetate (73 ml) was added and the mixture heated to 40° C. for 3 hours. Further ethyl bromoacetate (2.5 ml) and cesium carbonate (1 g) were added and heating continued for a further hour. The cooled reaction was filtered and the filtrate concentrated to give the title compound as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091237B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-5d337718b4324e0dae33ac3f4b6f3bab |
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| 出典メモ | uspto-grants-2006_08 |
|---|
