4-Chlorophenol → 1-Chloro-4-(2-chloroethoxy)benzene

HRID 962460

反応式

HRID 962460 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][Cl:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][Cl:12])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 46844-ChlorophenolHCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium Carbonate

生成物 1

HCID 830341-Chloro-4-(2-chloroethoxy)benzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 4-chlorophenol (100 g), 1-bromo-2-chloroethane (335 g), potassium carbonate (129 g) and acetone (2 l) was boiled under reflux with stirring for 18 hours. The mixture was evaporated to dryness under reduced pressure and then dichloromethane was added to the cool residue. The mixture was filtered and the filtrate washed with 5M sodium hydroxide solution, water, dried, filtered and evaporated to give 2-chloroethyl 4-chlorophenyl ether as an oil.

後処理

  1. temperatureunder reflux
  2. customThe mixture was evaporated to dryness under reduced pressure
  3. additiondichloromethane was added to the cool residue
  4. filtrationThe mixture was filtered
  5. washthe filtrate washed with 5M sodium hydroxide solution, water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-aa8d150336f2442bbe8ed61e251865ce
出典データセット
uspto-grants-1998_06
特許番号
US05760035

関連ノート

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