Methyl bromoacetate → 4-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-methoxycarbonylmethoxy ethoxy)methyl)piperidine Hydrochloride

HRID 962473

反応式

HRID 962473 の反応式
[ClH:1].[C:2]1([C:8]2([CH2:14][O:15][CH:16]([C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=3)[CH2:17][OH:18])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:34][C:35]([O:37][CH3:38])=[O:36]>>[ClH:1].[C:2]1([C:8]2([CH2:14][O:15][CH:16]([C:19]3[CH:24]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:22]=[C:21]([C:29]([F:32])([F:30])[F:31])[CH:20]=3)[CH2:17][O:18][CH2:34][C:35]([O:37][CH3:38])=[O:36])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 60984Methyl bromoacetateHCID 190847004-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy) methyl)piperidine Hydrochloride

生成物 1

HCID 190847104-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-methoxycarbonylmethoxy ethoxy)methyl)piperidine Hydrochloride

実験手順

This was prepared in a similar manner as Example 2 using the compound of Example 1 (d) and methyl bromoacetate. 1H NMR (360 MHz, d6 -DMSO) δ7.98 (1H, s), 7.75 (2H, s), 7.41-7.24 (5H, m), 4.68 (1H, t, J=5 Hz), 4.11 (2H, s), 3.62 (3H, s), 3.69-3.30 (4H, m), 3.29-3.10 (2H, m), 2.78-2.60 (2H, m), 2.39-2.00 (4H, m). MS (Cl+) 520 (M+H)+.

出典と根拠

ORDレコード
ord-f3f52798b3804666b2c0bfe925799aca
出典データセット
uspto-grants-1998_06
特許番号
US05760018

関連ノート

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