Methyl bromoacetate → 4-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-methoxycarbonylmethoxy ethoxy)methyl)piperidine Hydrochloride

関与物質

反応手順

Prepared from the compound of Example 1 (d) by the method of Example 2, using methyl bromoacetate in place of methyl iodide. 1H NMR (360 MHz, d6 -DMSO) δ 2.00-2.12 (2H, m), 2.24-2.35 (2H, m), 2.62-2.77 (2H, m), 3.17 (2H, br m), 3.29 (1H, d, J=6.0 Hz), 3.62 (3H, s+m), 4.01 (2H, s), 4.08 (1 H, t, J=6.0 Hz), 7.24-7.41 (5H, m), 7.68 (2H, s), 7.97 (1 H, s). MS (EI+) 520 (M+H+).

情報源と証拠