関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2,3,4,5-tetrahydro-1H-1-benzazepine-2,5-dione | HCID 369398 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934763 | 79% |
反応手順
A mixture of 0.250 g (1.43 mmol) of 3,4-dihydro-1H-1-benzazepine-2,5-dione and 5.5 ml (4.93 g, 41.5 mmol) of N,N-dimethylformamide, dimethylacetal is heated at 90° C. for 1.5 hour. The mixture is cooled, diluted with diethylether and filtered. The solid is washed well with diethylether and dried to give 0.26 g of tan crystals, m.p. 203°-205° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05760031 |
|---|
| 出典データセット | uspto-grants-1998_06 |
|---|
| ORD ID | ord-c43eb5fa51df4a9695601af50598cc59 |
|---|
| 出典メモ | uspto-grants-1998_06 |
|---|
