Water → Ethyl 4-{3-{4-(4-methylphenylmethoxy)-3-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl}indol-1-yl}butanoate

HRID 962766

反応式

HRID 962766 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:26]=[CH:25][C:13]([C:14]([C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[NH:18][CH:17]=3)=[O:15])=[CH:12][C:11]=2[O:27][CH2:28][CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][N:34]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[O:43][CH3:44])[CH2:33][CH2:32]2)=[CH:4][CH:3]=1.BrCC[CH2:48][CH2:49][CH2:50][C:51]([O-])=[O:52].[C:54](=O)([O-])[O-].[K+].[K+].O.CN(C)[CH:63]=[O:64]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:26]=[CH:25][C:13]([C:14]([C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[N:18]([CH2:48][CH2:49][CH2:50][C:51]([O:64][CH2:63][CH3:54])=[O:52])[CH:17]=3)=[O:15])=[CH:12][C:11]=2[O:27][CH2:28][CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][N:34]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[O:43][CH3:44])[CH2:33][CH2:32]2)=[CH:4][CH:3]=1

参加物

6

反応物 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 69998686-BromohexanoateHCID 22435861HCID 22435861、化合物

生成物 1

HCID 19085533Ethyl 4-{3-{4-(4-methylphenylmethoxy)-3-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl}indol-1-yl}butanoate

反応条件

温度
60 °C

実験手順

3-{4-(4-Methylphenylmethoxy)-3-{3-[4-(2-methoxyphenyl) piperazin-1-yl]propoxy}benzoyl}indole (0.12 g) obtained in Step 4 was dissolved in N,N-dimethylformamide (2 ml). 4-Bromoethylbutyrate (52 mg) and potassium carbonate (33 mg) were added to the resultant solution and stirred for 3 hours at 60° C. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The resultant extract was washed with brine and then dried. The solvent was distilled off. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1), obtaining 0.11 g of ethyl 4-{3-{4-(4-methylphenylmethoxy)-3-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl}-indol-1-yl}butanoate as a light brown oily substance.

後処理

  1. extractionfollowed by extraction with ethyl acetate
  2. extractionThe resultant extract
  3. washwas washed with brine
  4. customdried
  5. distillationThe solvent was distilled off
  6. customThe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1)

出典と根拠

ORDレコード
ord-5e926813a29041e49f6c8bc30f5304e4
出典データセット
uspto-grants-1998_06
特許番号
US05760040

関連ノート

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