Benzyl 4-(1,2,4-triazol-1-yl)butyrate → 4-(1H-1,2,4-triazol-1-yl)butanoic acid
反応式
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])[CH:5]=[N:4][CH:3]=[N:2]1.[H][H]>C(O)C.[C].[Pd]>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[N:4][CH:3]=[N:2]1参加物
5
実験手順
0.5 g of 5% palladium carbon was added to a solution of 11 g of benzyl 4-(1,2,4-triazol-1-yl)butyrate in 150 ml of ethanol. The mixture was stirred at a hydrogen pressure of 1 atm. at room temperature for 1 hour. Thereto was added 100 ml of ethanol. The mixture was heated and made uniform. Palladium carbon was collected by filtration and washed with ethanol. The filtrate and the washings were combined and concentrated under reduced pressure. To the residue was added a small amount of ethanol. The resulting insolubles were collected by filtration to obtain 6.2 g of 4-(1,2,4-triazol-1-yl)butyric acid as a white powder.
後処理
- temperatureThe mixture was heated
- filtrationPalladium carbon was collected by filtration
- washwashed with ethanol
- concentrationconcentrated under reduced pressure
- additionTo the residue was added a small amount of ethanol
- filtrationThe resulting insolubles were collected by filtration
出典と根拠
- ORDレコード
- ord-783e429c6fe2487393603243f974a672
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05760058
反応ノート
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