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2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → Ethyl 2-(benzofuran-3-yl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| 反応物 | 130106-48-8 | HCID 12171952 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethyl 2-(benzofuran-3-yl)acetate | HCID 7537531 | 75% |
反応手順
A toluene solution under N2 atmosphere containing ethyl 2,3-dihydrobenzo[b]furan-3-acetate (9.80 g, 47.6 mmol) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) (12.97 g, 57.1 mmol) was heated at reflux for ~8 h. The reaction was filtered and the filtrate concentrated in vacuo. Silica gel chromatography (97:3 Hexane:EtOAc) of the residue afforded the title compound (7.24 g, 75%) as an orange oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05763444 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-8d11f425710f41199cde8cd1c36120dd |
| 出典メモ | uspto-grants-1998_06 |