関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Lithium Carbonate | HCID 11125 | — |
| 反応物 | Ethanethiol, 2-(diethylamino)-, hydrochloride (1:1) | HCID 16031 | — |
| 反応物 | 10-chloro-8-hydroxy-11H-indeno[1,2-b]quinolin-11-one | HCID 19081815 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 10-(((dimethylamino)ethyl)thio)-8-hydroxy-11H-indeno[1,2-b]quinolin-11-one | HCID 22440208 | 63.2% |
反応手順
A mixture of 400 mg (1.4 mmol) of 10-chloro-8-hydroxy-11H-indeno[1,2-b]quinolin-11-one, 629 mg (8.5 mmol) of lithium carbonate, 963 mg (5.7 mmol) of 2-diethylaminoethanethiol hydrochloride and 8 ml of N,N-dimethylformamide was stirred for 5 hours with heating at 90° C. After completion of the reaction, the reaction mixture was added to water, and precipitated crystals were collected by filteration. The crystals were recrystallized from ethanol, giving 310 mg of the title compound (yield: 57.7%). The property values are shown in Table 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05763453 |
|---|
| 出典データセット | uspto-grants-1998_06 |
|---|
| ORD ID | ord-f77d3e454a19410ba31af60dc53a8981 |
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| 出典メモ | uspto-grants-1998_06 |
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