関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Bromosalicylaldehyde | HCID 72863 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | 2-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one | HCID 14913650 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methanone, (5-bromo-2-benzofuranyl)(5-methyl-2-phenyl-4-oxazolyl)- | HCID 10500081 | — |
反応手順
To a slurry of 294 g of 5-bromosalicylaldehyde in 3 liters of dry ethanol was added 79.06 g of sodium methoxide and the mixture allowed to stir for 20 minutes. To the resulting yellow slurry was added 410 g of 2-phenyl-4-bromoacetyl-5-methyloxazole and the slurry heated to 780° C. for 2 hours. An additional 250 mg of sodium methoxide was added and heating continued overnight under a nitrogen atmosphere. The reaction was cooled and the solids filtered and washed with ethanol, 393 g, mp 212°-213° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05763467 |
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| 出典データセット | uspto-grants-1998_06 |
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| ORD ID | ord-e6494d0301f6494d96d173641848b4df |
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| 出典メモ | uspto-grants-1998_06 |
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