関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one | HCID 19081861 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one | HCID 19081933 | 96.5% |
反応手順
1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one (0.72 g, 2.26 mmol), sodium iodide (0.15 g, 0.1 mmol), and piperidine (1.72 g, 20 mmol) were combined in DMF (8.0 mL) and the mixture was heated to 80° C. for 4.5 hours. Water was then added to form a precipitate. Filtration gave 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one (0.8 g, 2.18 mmol), m.p. 74°-75° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05763458 |
|---|
| 出典データセット | uspto-grants-1998_06 |
|---|
| ORD ID | ord-961cf621db1c4e61b496032ab17b2b88 |
|---|
| 出典メモ | uspto-grants-1998_06 |
|---|
