1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one → 1-(4-Amino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one hydrochloride

HRID 963344

反応式

HRID 963344 の反応式
C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:23])[CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[C:7]([O:24][CH3:25])[CH:6]=1)(=O)C>Cl>[ClH:11].[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:23])[CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)=[C:7]([O:24][CH3:25])[CH:6]=1

参加物

3

反応物 1

HCID 190819331-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one

生成物 1

HCID 97990091-(4-Amino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one hydrochloride

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one was dissolved in 2N hydrochloric acid (25 mL) and the solution was stirred for 30 minutes. The solution was cooled in an ice bath to form a precipitate. The precipitate was collected by filtration and washed with water. Drying in a vacuum oven at 70° C. gave 1-(4-amino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one hydrochloride (0.65 g, 2 mmol), m.p. 220°-221° C.

後処理

  1. temperatureThe solution was cooled in an ice bath
  2. customto form a precipitate
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customDrying in a vacuum oven at 70° C.

出典と根拠

ORDレコード
ord-e7075111ff684583a8c1202478ebea3d
出典データセット
uspto-grants-1998_06
特許番号
US05763458

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