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1-Bromopropane → 1-[4-Amino-5-chloro-2-(prop-1-yloxy)phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromopropane | HCID 7840 | — |
| 反応物 | 1-[4-Amino-5-chloro-2-methoxyphenyl]-5-(piperidin-1-yl)pentan-1-one | HCID 9799010 | — |
| 生成物 | 1-[4-Amino-5-chloro-2-(prop-1-yloxy)phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride | HCID 19081863 | — |
反応手順
Proceeding as in Example 12, Step (a), but replacing 1-(4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoeth yl]piperidin-4-yl}propan-1-one with 1-[4-amino-5-chloro-2-methoxyphen yl]-5-(piperidin-1-yl)pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with 1-bromopropane, gave 1-[4-amino-5-chloro-2-(prop-1-yloxy)phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride, m.p. 232°-233° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05763458 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-2b4c1eed333b4782bc7e667b689df354 |
| 出典メモ | uspto-grants-1998_06 |