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3,5-Dimethylbenzyl chloride → 1-[4-Amino-5-chloro-2-(3,5-dimethylbenzyloxy)-phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Dimethylbenzyl chloride | HCID 137700 | — |
| 反応物 | 1-[4-Amino-5-chloro-2-methoxyphenyl]-5-(piperidin-1-yl)pentan-1-one | HCID 9799010 | — |
| 生成物 | 1-[4-Amino-5-chloro-2-(3,5-dimethylbenzyloxy)-phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride | HCID 19081988 | — |
反応手順
Proceeding as in Example 12, Step (a), but replacing 1-(4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoethyl]piperidin-4-ylpropan-1-one with 1-[4-amino-5-chloro-2-methoxyphenyl]-5-(piperidin-1-yl)pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with 3,5-dimethylbenzyl chloride, gave 1-[4-amino-5-chloro-2-(3,5-dimethylbenzyloxy)-phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride, m.p. 218°-233° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05763458 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-0ea2869f10b2413c86aeb4f10f31f03f |
| 出典メモ | uspto-grants-1998_06 |