化工社化工社 化学情報印刷レポート · 研究参考用
5-Iodosalicylic acid → N-cyclopropyl-2-hydroxy-5-iodo-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Iodosalicylic acid | HCID 8388 | — |
| 反応物 | Carbon tetrabromide | HCID 11205 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-cyclopropyl-2-hydroxy-5-iodo-benzamide | HCID 19081760 | 18.1% |
反応手順
13bh) A mixture of 2.64 g of 2-hydroxy-5-iodo-benzoic acid, 0.69 g of cyclopropylamine and 3.65 g of carbon tetrabromide in 40 ml of methylene chloride is treated portionwise at room temperature with 2.62 g of triphenylphosphine. After 2 hrs. the mixture is filtered and the filtrate is concentrated. Chromatography on silica gel with ethyl acetate/cyclohexane 1:4 gives 550 mg of crude N-cyclopropyl-2-hydroxy-5-iodo-benzamide. Yield: 18%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05763450 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-306d3aab035e4e08a8f3d9d6b64efce8 |
| 出典メモ | uspto-grants-1998_06 |