関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Triethylamine hydrochloride | HCID 11130 | — |
| 反応物 | 3-Nitrobenzonitrile | HCID 12079 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 5-(3-nitrophenyl)tetrazole | HCID 285129 | 93.1% |
反応手順
A mixture of 3-nitrobenzonitrile (3.70 g, 25 mmol), sodium azide (4.88 g, 75 mmol) and triethylamine hydrochloride (10.32 g, 75 mniol) in N-methylpyrrolidone (55 ml) was heated at 130° C. for 2 hours under stirring. The reaction mixture was poured into ice-water, to which was dropwise added 6N hydrochloric acid in order to acidify. The resultant precipitates were collected by filtration, washed with water and dried to afford 5-(3-nitrophenyl)-1H-tetrazole (4.45 g, 93.1%), which was used in a following reaction without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05763437 |
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| 出典データセット | uspto-grants-1998_06 |
|---|
| ORD ID | ord-b4977d2e8dce40dd8945e276bc302e29 |
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| 出典メモ | uspto-grants-1998_06 |
|---|
