Hydrochloric Acid → Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

HRID 963642ノート

反応式

HRID 963642 の反応式
C([S:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([O:29]CC)(=[O:28])[O:25]CC)([P:16]([O:21]CC)(=[O:20])[O:17]CC)[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2)(=O)C.Cl>>[SH:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([OH:29])(=[O:25])[OH:28])([P:16]([OH:21])(=[O:17])[OH:20])[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 86752760Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester

生成物 1

HCID 86752761Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

実験手順

Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester (4.0 mmol) is added to 6N HCl (35 ml) and heated at reflux under nitrogen for 18 hours. The reaction mixture is then cooled and concentrated under reduced pressure. The product is obtained by recrystallizing from water and isopropanol.

後処理

  1. temperatureheated
  2. temperatureat reflux under nitrogen for 18 hours
  3. temperatureThe reaction mixture is then cooled
  4. concentrationconcentrated under reduced pressure
  5. customThe product is obtained
  6. customby recrystallizing from water and isopropanol

出典と根拠

ORDレコード
ord-1601c17761b34246994f7fce36b6dcf2
出典データセット
uspto-grants-1998_06
特許番号
US05763611

反応ノート

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