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Phosgene → 2-(2-Chloro-6-nitrophenyl)ethoxycarbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | 2-(2-Chloro-6-nitrophenyl)ethanol | HCID 700810 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(2-Chloro-6-nitrophenyl)ethoxycarbonyl chloride | HCID 19082692 | 97% |
反応手順
Phosgene was introduced in a solution of 2-(2-chloro-6-nitrophenyl)ethanol (31 g, 154 mmol) in THF (190 ml, dist. over CaH2) at room temperature under stirring. After 2.5 h the excess phosgene and the solvent were removed by distillation in a high vacuum. 2-(2-chloro-6-nitrophenyl)ethoxycarbonyl chloride (39.4 g, 97%) was obtained as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05763599 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-5eea3744c2ce48369a72f21b65a68c3e |
| 出典メモ | uspto-grants-1998_06 |