Trimethyl orthoformate → Benzene, 1-(dimethoxymethyl)-3-methoxy-

HRID 963776ノート

反応式

HRID 963776 の反応式
C(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[CH:3]=1.[CH:11]([O:16][CH3:17])([O:14][CH3:15])OC.C(=O)(O)[O-].[Na+]>CO>[CH3:17][O:16][CH:11]([O:14][CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[CH:3]=1

参加物

5

反応物 3

HCID 9005Trimethyl orthoformateHCID 115693-MethoxybenzaldehydeHCID 516892Sodium Bicarbonate

生成物 1

HCID 10910282Benzene, 1-(dimethoxymethyl)-3-methoxy-

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

m-Anisaldehyde (204.3 g, 1.5 mol) was placed in a 1 liter flask under an argon atmosphere. Trimethyl orthoformate (191 g, 1.8 mol) was added quickly, followed by 150 ml anhydrous methanol. Amberlyst XN-1010 resin (2.1 g, Aldrich Chemical Co.), which had been previously boiled with methanol was added. The mixture was stirred at room temperature for 22 hours with the exclusion of moisture. Sodium bicarbonate (1.5 g) was added with stirring. After 20 minutes the mixture was filtered under vacuum into a 2 liter flask which was placed on the rotory evaporator with the water bath temperature at 40° C. Over 30 minutes the bath was heated to 80° to produce a clear, colorless oil. With magnetic stirring, the oil was pumped at 65° under vacuum (2 mm Hg) for 30 minutes. The resulting product weighted 272.5 g (99.8%). I.R. (near, cm-1): 2935, 2824, 1598, 1584, 1350, 1258, 1100, 1050, 984, 772. 1HNMR (400 MHz, CDCl3): δ3.33 (6H, s, OCH3); 3.81 (3H, s, ArOCH3); 5.35 (1H, s, ArCH(OCH3)2 ; 6.87 (1H, br d, 8.1 Hz); 7.00-7.03 (2H, m); 7.27 (1H, t, 8.1 Hz). These data indicated that the product was pure enough for use in the next step and were consistent with the following structure: ##STR28##

後処理

  1. additionwas added
  2. stirringwith stirring
  3. filtrationAfter 20 minutes the mixture was filtered under vacuum into a 2 liter flask which
  4. customwas placed on the rotory evaporator with the water bath temperature at 40° C
  5. temperatureOver 30 minutes the bath was heated to 80°
  6. customto produce a clear, colorless oil
  7. waitWith magnetic stirring, the oil was pumped at 65° under vacuum (2 mm Hg) for 30 minutes

出典と根拠

ORDレコード
ord-c286029c1db54593bb6103d60e620696
出典データセット
uspto-grants-1998_06
特許番号
US05763681

反応ノート

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