Hydrochloric Acid → H-(L)-Pal-NH2
反応式
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH2:12])=[O:11])[CH2:3][C:4]1[CH:9]=[N:8][CH:7]=[CH:6][CH:5]=1.Cl>C(Cl)Cl.O1CCOCC1>[NH2:1][C@H:2]([C:10]([NH2:12])=[O:11])[CH2:3][C:4]1[CH:9]=[N:8][CH:7]=[CH:6][CH:5]=1参加物
5
実験手順
Suspend Boc-(L)-Pal-NH2 (0.98 g) in methylene chloride (15 mL) with light heating and add a solution of hydrochloric acid (4M, 10 mL) in dioxane. After 30 minutes evaporate methylene chloride and dioxane. Dissolve the solid in methanol, precipitate by addition of ether and filtrate to give H-(L)-Pal-NH2. 2HCl (0.86 g, 98%).
後処理
- temperatureheating
- customAfter 30 minutes evaporate methylene chloride and dioxane
- dissolutionDissolve the solid in methanol
- additionprecipitate by addition of ether and filtrate
出典と根拠
- ORDレコード
- ord-d6373623d39543ca934f731c9d5e46e1
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05766932
反応ノート
読み込み中…