Dichloromethane → HCID 131719898、化合物
反応式
[C:1]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].F[B-](F)(F)F.[H+].[CH2:24](Cl)Cl>>[C:1]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH3:24])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a vigorously stirred mixture of BocNH(CH2)8OH (392 mg, 1.6 mmol) and fluoroboric acid (210 μL, 1.6 mmol) in DCM (8 mL), the TMS CHN2 (800 μL, 1.6 mmol) was added dropwise at 0° C. The solution was stirred at 0° C. and three further additions of TMS CHN2 (400 μL, 0.8 mmol and 200 μL×2, 0.4 mmol) were added at 15-minute intervals. The mixture was stirred for a further 4 hours after which starting material was still visible by t.l.c. but no further evolution of the reaction was however apparent.
後処理
- stirringThe mixture was stirred for a further 4 hours after which
出典と根拠
- ORDレコード
- ord-5bfce3735a0541afb35deb4b1c77f9c9
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05767088
反応ノート
読み込み中…