Ethyl Acetate → 2-(4,4-Diphenylbutyl)-5-hydroxyisoquinolinium bromide

HRID 963980ノート

反応式

HRID 963980 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[Br:12][CH2:13][CH2:14][CH2:15][CH:16]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(OCC)(=O)C>CN(C=O)C>[Br-:12].[C:17]1([CH:16]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:15][CH2:14][CH2:13][N+:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[OH:1])[CH:7]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 30386Isoquinolin-5-olHCID 122234581,1-Diphenyl-4-bromobutane

生成物 1

HCID 158708932-(4,4-Diphenylbutyl)-5-hydroxyisoquinolinium bromide収率 69.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

A mixture of 5-hydroxyisoquinoline (2.17 g, 14.95 mmol) and 1-bromo-4,4-diphenylbutane (4.79 g, 16.56 mmol) in 75 mL of anhydrous DMF was stirred at 80° C. for 16 hours. The reaction mixture was cooled to room temperature. Ethyl acetate (200 mL) was added to precipitate product. The solid was collected by filtration and washed with ethyl acetate (1×70 mL). The solid was air-dried to give 4.52 g of product as an off-white solid.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customto precipitate product
  3. filtrationThe solid was collected by filtration
  4. washwashed with ethyl acetate (1×70 mL)
  5. customThe solid was air-dried

出典と根拠

ORDレコード
ord-cdcbb52ef3a04fea8042aa5de75d6e0d
出典データセット
uspto-grants-1998_06
特許番号
US05767129

反応ノート

読み込み中…