2-Methoxyaniline → 4-Carbamoyl-1-(2-methoxyphenyl)-pyridinium chloride

HRID 963986ノート

反応式

HRID 963986 の反応式
[Cl-:1].[C:2]([C:5]1[CH:10]=[CH:9][N+:8]([C:11]2[CH:16]=[CH:15][C:14]([N+]([O-])=O)=[CH:13][C:12]=2[N+]([O-])=O)=[CH:7][CH:6]=1)(=[O:4])[NH2:3].[CH3:23][O:24]C1C=CC=CC=1N>CO>[Cl-:1].[C:2]([C:5]1[CH:10]=[CH:9][N+:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:24][CH3:23])=[CH:7][CH:6]=1)(=[O:4])[NH2:3]

参加物

4

反応物 2

HCID 70002-MethoxyanilineHCID 106160034-Carbamoyl-1-(2,4-dinitrophenyl)pyridinium chloride

生成物 1

HCID 106353734-Carbamoyl-1-(2-methoxyphenyl)-pyridinium chloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-carbamoyl-1-(2,4-dinitrophenyl)-pyridinium chloride (13.6 g), 2-methoxyaniline (10 ml) and methanol (500 ml) was stirred at ambient temperature for 16 hours and the solvent was removed in vacuo. Ether containing a small amount of acetone was added and the mixture heated under reflux until solidification of the product was complete. The product was collected by filtration to give 4-carbamoyl-1-(2-methoxyphenyl)-pyridinium chloride as a yellow solid (11.5 g), m.p. 229°-230° C. (dec).

後処理

  1. customthe solvent was removed in vacuo
  2. additionEther containing a small amount of acetone was added
  3. temperaturethe mixture heated
  4. temperatureunder reflux until solidification of the product
  5. filtrationThe product was collected by filtration

出典と根拠

ORDレコード
ord-c04ca881ae73424bab6d8c70154e9363
出典データセット
uspto-grants-1998_06
特許番号
US05767116

反応ノート

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