Oxalic Acid → HCID 87238501、化合物
反応式
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3]>C(O)C.O>[OH2:3].[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3]参加物
3
試薬・触媒・溶媒 1
実験手順
Analogously to Example 7 a solution of 2.3 g sodium phenolate and 2.5 g N-3-chloropropyl-N-[5-(4-fluorophenyl)-3-pyridylmethyl]-amine [obtainable by reaction of 3-hydroxypropylamine with 3-chloromethyl-5-(4-fluorophenyl)-pyridine and subsequent transformation of the product to the 3-chloropropyl-compound by reaction with PCl3 ] in 200 ml of acetonitrile is stirred for 5 hours at room temperature and worked up in a conventional manner to give N-(3-phenoxy-propyl)-N-[5-(4-fluorophenyl)-3-pyridyl-methyl]-amine. Stirring with Q5 equivalents of oxalic acid in 100 ml ethanol/water mixture gives the oxalate-hemihydrate, m.p. 217°.
出典と根拠
- ORDレコード
- ord-8d963b9d660c4eba8c897e732f901d24
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05767132
反応ノート
読み込み中…