Thiazolidinedione → 2,4-Thiazolidinedione, 5-(2-thienylmethylene)-, (Z)-
反応式
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[S:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH:13]=O.N1CCCCC1>C(O)C>[S:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH:13]=[C:5]1[S:1][C:2](=[O:7])[NH:3][C:4]1=[O:6]参加物
5
実験手順
To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 16.0 ml (171 mmol) of 2-thiophenecarboxaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 24.03 g of the desired compound (66.6% yield, pale yellow crystals).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 5 hours
- temperatureAfter cooling
- filtrationthe precipitated crystals were filtered
- washwashed with cooled ethanol
出典と根拠
- ORDレコード
- ord-eb396ceeb6c04f3a8b1904bf9a8c86f4
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05767121
反応ノート
読み込み中…