反応式
[B].C[C@H]1CC(=[O:8])[C@H](C(C)C)CC1.C(N[C@H:22]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C@H:23](O)[C:24]([O:26][C:27](C)(C)[CH3:28])=[S:25])(=O)C1C=CC=CC=1.CO[C@](C1C=CC=CC=1)(C(F)(F)F)C(O)=O.C1(N=C=NC2CCCCC2)CCCCC1>ClCCl.CN(C)C1C=CN=CC=1>[C:27]([O:26][C:24](=[S:25])[CH2:23][CH2:22][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)(=[O:8])[CH3:28]参加物
8
反応物 5
生成物 1
試薬・触媒・溶媒 2
実験手順
A pure sample of tertbutyl 3(R)-benzoylamino-2(S)-hydroxy-3-phenylthiopropionate was obtained via the same reaction sequence, but using the boron reagent di{[(1S,2S,5R)-2-isopropyl-5-methylcyclohex-1-yl]-methyl}boron bromide, derived from (-)menthone. Compound tertbutyl 3(R)-benzoylamino-2(S)-hydroxy-3-phenylthiopropionate was treated with excess (S)-(-)-α-methoxy-α-(trifluoromethyl) phenylacetic acid in dichloromethane in the presence of 1,3-dicyclohexylcarbodiimide (DCC) and catalytic 4-dimethylaminopyridine (DMAP). The Mosher derivative tertbutyl 3(R)-benzoylamino-2(S)-O-[(S)-α-methoxy-α-trifluoromethyl)phenyl]acetyl-3-phenylthiopropionate was obtained:
出典と根拠
- ORDレコード
- ord-161ad47b2c054bd398e35e0a3f26f471
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05767282
関連ノート
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