Imidazole → HCID 22097613、化合物

HRID 964581ノート

反応式

HRID 964581 の反応式
[CH2:1]([O:8][C:9](=[O:14])[CH2:10][CH2:11][CH2:12]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([O:8][C:9](=[O:14])[CH2:10][CH2:11][CH2:12][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 3832489Benzyl 4-bromobutanoate

生成物 1

HCID 22097613HCID 22097613、化合物収率 33%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 4-bromobutyric acid benzyl ester (23.7 g), imidazole (8.1 g), potassium carbonate (14.0 g) and acetone (400 ml) was stirred under refluxing conditions for 6 hours. After the reaction mixture was cooled to room temperature, the insoluble solid was filtered off, the filtrate was concentrated. The residual oily substance was subjected to silica gel column chromatography and eluted with ethyl acetate-methanol (20:1, v/v) to yield 4-(1-imidazolyl)butyric acid benzyl ester (7.3 g, 33%) as an oily substance.

後処理

  1. filtrationthe insoluble solid was filtered off
  2. concentrationthe filtrate was concentrated
  3. washeluted with ethyl acetate-methanol (20:1

出典と根拠

ORDレコード
ord-3ed45cadc4b34ceba705c957520c258a
出典データセット
uspto-grants-1998_06
特許番号
US05770602

反応ノート

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