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Sodium Hydroxide → {2-Nitro-5-[(undec-10-en-1-yl)oxy]phenyl}methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Silane | HCID 23953 | — |
| 反応物 | 3-(Hydroxymethyl)-4-nitrophenol | HCID 108946 | — |
| 反応物 | Undecylenic bromide | HCID 21705948 | — |
| 触媒 | Benzenemethanaminium, N,N,N-tributyl-, bromide | HCID 2724282 | — |
| 生成物 | {2-Nitro-5-[(undec-10-en-1-yl)oxy]phenyl}methanol | HCID 19074081 | — |
反応手順
Synthesis of a o-nitrobenzyl PEG-silane of the above formula wherein R3 is H and m=11 was achieved in three steps. First, 5-hydroxy-2-nitrobenzyl alcohol I in 0.3 NaOH was refluxed for four days with undecylenic bromide II (dissolved in CH2Cl2) in the presence of benzyltributylammonium bromide to form 2-nitro-5-(10-undecenyloxy)phenylmethanol III according to the following reaction scheme: ##STR6##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05773308 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-4e4e5ae11cbe458e8e3a31c676e798a5 |
| 出典メモ | uspto-grants-1998_06 |