Azane;hydrate → HCID 135990571、化合物

反応式

[I:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([C:11]([F:14])([F:13])[F:12])[O:8][C:9](=O)[C:4]=2[CH:3]=1.O.[NH3:18]>>[I:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:15][CH:16]=1)[N:6]=[C:7]([C:11]([F:14])([F:13])[F:12])[NH:18][C:9]2=[O:8]

参加物

反応物 2

HCID 12896473Azane;hydrate

HCID 17349916HCID 17349916、化合物

生成物 1

HCID 135990571HCID 135990571、化合物

実験手順

6-iodo-2-trifluoromethyl-benzo[d][1,3]oxazin-4-one (0.6 g, 1.76 mmole) was stirred with 25 mL of concentrated ammonia water at 40° C. for 5 h, cooled to 0C, the precipitate was filtered and dried under vacuo. The product was recrystallized from ethyl acetate and haxanes to give 0.58 g, mp >255° C. (sub), MS (CI) m/z 341 (MH)+.

後処理

filtrationthe precipitate was filtered
customdried under vacuo
customThe product was recrystallized from ethyl acetate and haxanes
customto give 0.58 g, mp >255° C. (sub), MS (CI) m/z 341 (MH)+

出典と根拠

ORDレコード: ord-01606c0ad9814aaf9feba542eafca058
出典データセット: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05773444

反応ノート

読み込み中…

参加物