Thiourea → 7-Nitroquinoline-4(1H)-thione
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.NC(N)=[S:17]>C(O)C>[N+:12]([C:8]1[CH:7]=[C:6]2[C:11]([C:2](=[S:17])[CH:3]=[CH:4][NH:5]2)=[CH:10][CH:9]=1)([O-:14])=[O:13]参加物
4
反応条件
- 温度
- 80 °C
実験手順
4-Chloro-7-nitroquinoline (100 mg, 0.48 mmol) and thiourea (100 mg, 1.3 mmol) were added to ethanol (50 ml) and stirred at 80° C. for 30 minutes. After allowing to cool to room temperature, ethanol was removed under reduced pressure. The residue was chromatographed by silica gel column chromatography and eluted with mixed solution of methylene chloride with methanol (19 : 1) for collection of yellow bands. The solvent was removed to obtain 7 mg (7%) of the titled yellow compound.
後処理
- temperatureto cool to room temperature
- customethanol was removed under reduced pressure
- customThe residue was chromatographed by silica gel column chromatography
- washeluted with mixed solution of methylene chloride with methanol (19 : 1) for collection of yellow bands
- customThe solvent was removed
- customto obtain 7 mg (7%) of the titled yellow compound
出典と根拠
- ORDレコード
- ord-a6262e162148456bb565a1479526dd3f
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05773449
反応ノート
読み込み中…