Aluminium lithium hydride → (+/-) trans 1-(Phenylthio)-2-methylaminoindane
反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].[C:7]1([S:13][C@@H:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C@H:15]2[NH:23][C:24](OCC)=O)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(OCC)C>[C:7]1([S:13][C@@H:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C@H:15]2[NH:23][CH3:24])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1参加物
4
実験手順
To a stirred suspension of LiAlH4 (0.22 g, 5.7 mmol) in dry diethyl ether (10 ml) under nitrogen was added a solution of (±) trans 1-(phenylthio)-2-ethoxycarbonylaminoindane (0.36 g, 1.15 mmol) in diethyl ether (15 ml). After stirring overnight at room temperature the reaction was worked up as described in Preparation 4 to give the title compound as a brown oil (0.27 g) which was used in the next stage without purification.