Carbon Dioxide → HCID 178516780、化合物

HRID 965391ノート

反応式

HRID 965391 の反応式
NC[C:3]([C:5]1[N:6]=[CH:7][N:8]([C@@H:15]2[O:20][C@H:19]([CH2:21][OH:22])[C@@H:17]([OH:18])[C@H:16]2[F:23])[C:9]=1[N:10]=[CH:11][N:12](C)[CH3:13])=[O:4].C[O-].[Na+].C(=O)=O>CO>[F:23][C@@H:16]1[C@H:17]([OH:18])[C@@H:19]([CH2:21][OH:22])[O:20][C@H:15]1[N:8]1[C:9]2[N:10]=[CH:11][NH:12][CH2:13][C:3](=[O:4])[C:5]=2[N:6]=[CH:7]1

参加物

5

反応物 3

HCID 280Carbon DioxideHCID 10942334Sodium MethoxideHCID 537945224-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole

生成物 1

HCID 178516780HCID 178516780、化合物収率 36%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

The compound (24) (20 mg) obtained in item (13) above was dissolved in methanol (0.4 ml), to which was added a 0.2M sodium methylate solution (0.4 ml) in methanol and the resulting mixture was allowed to stand at room temperature overnight. The reaction solution obtained was neutralized with addition of dry ice, then concentrated to leave a residue and the residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1), affording the titled compound (25) (6.2 mg) as a colorless solid. Yield: 36%.

後処理

  1. customThe reaction solution obtained
  2. concentrationconcentrated
  3. customto leave a residue
  4. customthe residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1)

出典と根拠

ORDレコード
ord-72725a9bf49c499bbb287d7a09bafc34
出典データセット
uspto-grants-1998_06
特許番号
US05773607

反応ノート

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