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Chlorine → 1,2-Benzisothiazol-3(2H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorine | HCID 24526 | — |
| 反応物 | Sulfuryl chloride | HCID 24648 | — |
| 反応物 | 2-(Methylthio)benzaldehyde oxime | HCID 786757 | — |
| 溶媒 | Chlorobenzene | HCID 7964 | — |
| 生成物 | 1,2-Benzisothiazol-3(2H)-one | HCID 17520 | 91.1% |
反応手順
From the monochlorobenzene layer obtained by the same procedures as in Example 1, 2-(methylthio)benzaldehyde oxime was isolated in the same manner as in Example 2. 39.7 g of the oxime isolated was dissolved in 150 g of monochlorobenzene. Then, the oxime was cyclized in the same manner as in Example 1 except that chlorine was changed to 35.3 g (0.26 mol) of sulfuryl chloride. As a result, 32.7 g of 1,2-benzisothiazol-3-one was obtained. The yield against 2-(methylthio)benzaldehyde oxime was 91%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05773626 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-5487ba3d2dad411c91c81364658c44ca |
| 出典メモ | uspto-grants-1998_06 |