Ethyl cyanoacetate → 6,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester

HRID 965783ノート

反応式

HRID 965783 の反応式
[OH:1][C:2]1[CH:9]=[C:8]([OH:10])[C:7]([OH:11])=[CH:6][C:3]=1[CH:4]=O.[C:12]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])#[N:13]>CN(C=O)C.N1CCCCC1.C(O)(=O)C>[CH2:18]([O:17][C:15]([C:14]1[C:12](=[NH:13])[O:1][C:2]2[C:3]([CH:4]=1)=[CH:6][C:7]([OH:11])=[C:8]([OH:10])[CH:9]=2)=[O:16])[CH3:19]

参加物

6

反応物 2

HCID 7764Ethyl cyanoacetateHCID 6433872,4,5-Trihydroxybenzaldehyde

生成物 1

HCID 1363776256,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester

試薬・触媒・溶媒 3

HCID 176Acetic Acid触媒HCID 8082Piperidine触媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 2,4,5-trihydroxybenzaldehyde (2.94 g) and ethyl cyanoacetate (1.62 g) in DMF (20 ml) were added 20 drops (Pasteur pipette) of piperidine and eight drops of acetic acid and the solution kept at 80° C. under nitrogen for two hours. The product was filtered and washed with DMF and ethyl ether. Yield: 2.00 g.

後処理

  1. filtrationThe product was filtered
  2. washwashed with DMF and ethyl ether

出典と根拠

ORDレコード
ord-3c8480c2150a4cc39986f0d6baa4f641
出典データセット
uspto-grants-2005_10
特許番号
US06951870B2

反応ノート

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