Oxalic Acid → 5-AMINO-6-CHLORO-2-ETHYL-N-{[1-(2-HYDROXYBUTYL)PIPERIDIN-4-YL]METHYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE OXALATE

HRID 965810ノート

反応式

HRID 965810 の反応式
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH:24]([OH:27])[CH2:25][CH3:26])[CH2:19][CH2:18]2)=[O:14])=[CH:4][C:3]=1[Cl:28].[C:29]([OH:34])(=[O:33])[C:30]([OH:32])=[O:31]>CO>[C:29]([OH:34])(=[O:33])[C:30]([OH:32])=[O:31].[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:15][CH2:16][CH:17]2[CH2:18][CH2:19][N:20]([CH2:23][CH:24]([OH:27])[CH2:25][CH3:26])[CH2:21][CH2:22]2)=[O:14])=[CH:4][C:3]=1[Cl:28]

参加物

4

反応物 2

HCID 971Oxalic AcidHCID 103413815-amino-6-chloro-2-ethyl-N-{[1-(2-hydroxybutyl)piperidin-4-yl]methyl}-imidazo[1,2-a]pyridine-8-carboxamide

生成物 1

HCID 223132655-AMINO-6-CHLORO-2-ETHYL-N-{[1-(2-HYDROXYBUTYL)PIPERIDIN-4-YL]METHYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE OXALATE収率 142.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

5-amino-6-chloro-2-ethyl-N-{[1-(2-hydroxybutyl)piperidin-4-yl]methyl}-imidazo[1,2-a]pyridine-8-carboxamide (Example 13, Step 3, 79 mg, 0.19 mmol) was dissolved in methanol (3 mL) and acidified with oxalic acid (17.4 mg, 0.13 mmol) in methanol (2 mL). The mixture was then concentrated and a white precipitate was washed with ethyl acetate to afford (92 mg, 80%) of the title compound.

後処理

  1. concentrationThe mixture was then concentrated
  2. washa white precipitate was washed with ethyl acetate

出典と根拠

ORDレコード
ord-51e857823e564950b4b992938bd17c0f
出典データセット
uspto-grants-2005_10
特許番号
US06951867B2

反応ノート

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