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Dimethyl Sulfate → 6-(2-p-Tolyl-vinyl)-pyridine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 2-(2-p-Tolyl-vinyl)-pyridine 1-oxide | HCID 69592129 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 6-(2-p-Tolyl-vinyl)-pyridine-2-carbonitrile | HCID 69592042 | — |
反応手順
In a variation to the procedure referred to in example 1, 2-(2-p-tolyl-vinyl)-pyridine 1-oxide (9.8 g, 46 mmol) was reacted first with dimethylsulfate ( 5.8 g, 46 mmol) and then with NaCN (2.74 g, 56 mmol). After extraction and crystallization 6-(2-p-tolyl-vinyl)-pyridine-2-carbonitrile (5.8 g, 57%) was obtained as a yellow crystalline material. Mp. 137-138° C. (isopropanol), MS: m/e=220 (M+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06951875B2 |
| 出典データセット | uspto-grants-2005_10 |
| ORD ID | ord-4f80f94ca7fb497abb25fde0d2a3ffae |
| 出典メモ | uspto-grants-2005_10 |