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Benzaldehyde → trans-2-Methyl-4-styryl-pyridine 1-oxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | 2,4-Dimethylpyridine 1-oxide | HCID 70733 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 生成物 | trans-2-Methyl-4-styryl-pyridine 1-oxide | HCID 22176472 | 7% |
反応手順
Following the general method described in example 2a, 2,4-dimethylpyridine 1-oxide was reacted with potassium tert.-butanolate and benzaldehyde. After extraction and chromatography (SiO2 with CH2Cl2/MeOH=97/3) the title compound was obtained as a yellow solid material (yield 7%)). NMR (250 MHz, DMSO): 2.37 (s, 3H, CH3), 7.20 (d, J=16.5 Hz, 1H, CH═CH), 7.25-7.75 (m, 8H, arom-H, CH═CH), 8.22 (d, J=6.8 Hz, 1H, arom-H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06951875B2 |
| 出典データセット | uspto-grants-2005_10 |
| ORD ID | ord-2de06ad5f59549849d5cd25caec72925 |
| 出典メモ | uspto-grants-2005_10 |