Hydrochloric Acid → 5-[4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide hydrochloride
反応式
[Cl:1][C:2]1[C:3]([C:28]([F:31])([F:30])[F:29])=[N:4][N:5]([C:18]2[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[N:22][CH:23]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[CH:15][S:16][CH:17]=2)=[CH:9][CH:8]=1.Cl>ClCCl>[ClH:1].[Cl:1][C:2]1[C:3]([C:28]([F:31])([F:29])[F:30])=[N:4][N:5]([C:18]2[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:25])=[O:26])=[N:22][CH:23]=2)[C:6]=1[C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[CH:15][S:16][CH:17]=2)=[CH:11][CH:12]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
To a solution of 5-{4-chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide (200 mg, 0.412 mmol) in dichloromethane (6 ml) was added methanolic hydrochloric acid (2 ml) at room temperature. The solution stood for a while and a formed solid was collected to give 160 mg (74%) of the title compound as a white solid.