2-Acetylbutyrolactone → HCID 178432037、化合物

HRID 965992ノート

反応式

HRID 965992 の反応式
Br.[NH2:2][C:3]1[NH:7][N:6]=[C:5]([CH3:8])[C:4]=1[Br:9].[C:10]([CH:13]1[CH2:18][CH2:17][O:16][C:14]1=[O:15])(=O)[CH3:11]>C(O)C>[Br:9][C:4]1[C:5]([CH3:8])=[N:6][N:7]2[C:14]([OH:15])=[C:13]([CH2:18][CH2:17][OH:16])[C:10]([CH3:11])=[N:2][C:3]=12

参加物

4

反応物 2

HCID 106012-AcetylbutyrolactoneHCID 178419529HCID 178419529、化合物

生成物 1

HCID 178432037HCID 178432037、化合物収率 31.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 5-amino-4-bromo-3-methylpyrazole hydrobromide (13 g, 51 mmol) and α-acetyl-γ-butyrolactone (6.8 g, 53 mmol) in ethanol (65 mL) was heated under reflux for nine hours. After cooling to room temperature, the resulting crystals were collected by filtration, to give the title compound (4.6 g) as white crystals.

後処理

  1. temperatureunder reflux for nine hours
  2. filtrationthe resulting crystals were collected by filtration

出典と根拠

ORDレコード
ord-301fb18165de450c9d1f7329c9ad1eec
出典データセット
uspto-grants-2005_10
特許番号
US06951865B2

反応ノート

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