2-Acetylbutyrolactone → 3-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanone

HRID 966024

反応式

HRID 966024 の反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9]([CH:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])(=O)[CH3:10]>C(O)C>[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH:5][C:9](=[C:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])[CH3:10]

参加物

4

反応物 2

HCID 106012-AcetylbutyrolactoneHCID 122713-Iodoaniline

生成物 1

HCID 695835373-[1-(3-Iodoanilino)ethylidene]tetrahydro-2-furanone収率 99.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3-iodoaniline (5.0 g, 23 mmol), α-acetyl-γ-butyrolactone (14.6 g, 0.11 mol) in ethanol (100 mL) was heated under reflux for seven days. The mixture was evaporated, and the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (7.54 g) as white crystals.

後処理

  1. temperatureunder reflux for seven days
  2. customThe mixture was evaporated
  3. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-5a95d79f963c47cfb60e1135f1379845
出典データセット
uspto-grants-2005_10
特許番号
US06951865B2

関連ノート

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